Large Deformation Characterization of Mouse Oocyte Cell Under Needle Injection Experiment

Document Type : Research Article

Authors

1 Corresponding Author, School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran, Email: Ali.eng.edu@gmail.com.

2 Center of Excellence in Design, Robotics and Automation (CEDRA), School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.

Abstract

In order to better understand the mechanical properties of biological cells, characterization and investigation of their material behavior is necessary. In this paper hyperelastic Neo-Hookean material is used to characterize the mechanical properties of mouse oocyte cell. It has been assumed that the cell behaves as continuous, isotropic, nonlinear and homogenous material for modeling. Then, by matching the experimental data with finite element (FE) simulation result and using the Levenberg–Marquardt optimization algorithm, the nonlinear hyperelastic model parameters have been extracted. Experimental data of mouse oocyte captured from literatures. Advantage of the developed model is that it can be used to calculate accurate reaction force on surgical instrument or it can be used to compute deformation or force in virtual reality based medical simulations.

Keywords

References

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